As a side note, this is one of my favorite cards from the Nuclear Fallout Nuclear Fallout is of course best in decks that synergize with rad counters, but the real win comes from how much value you gain from its variable mana value
It might be that the best route is mana rocks, but well see what this set of commanders leads to
Permanents with Hexproof or Indestructible I just do not find the play pattern of thing you are literally not allowed to interact with unless you have this very specific answer to be particularly fun
Phyrexian Vindicator is an excellent back up plan therefore, as basically the only other card in your deck aside from Stuffy Doll that will make a good target for all those spells
EDHREC players, for example, run this pretty frequently in Tinybones, Trinket Thief, Tinybones, Bauble Burglar, and Tergrid, God of Fright, all commanders that excel leading decks that aim to whittle opponents down to zero resources as soon as possible
Almost everything you do is rewarded in some way, as the game hurls booster packs, special cards, gold and mastery orbs at you