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This compares very nicely to Commander Classic (CC) Karmic Guide, in 50,000 decks over at EDHREC.com

If you want to win with red, you have to win fast , and ideally out of nowhere

Yawgmoth, Thran Physician allows you to pay life and sacrifice creatures to spread -1/-1 counters around and draw cards

Just like the Construct suggests, I really like this with artifact tokens like the recent Soldiers, Thopters, Myr, Servos, and more

If you want to remove it via a Disenchant or Naturalize-like effect, this black permanent also boasts a proto-ward effect: if it's targeted by a spell, the spells controller loses a not-insubstantial five life

Its a fun tech card for commanders like Blim, Comedic Genius or Zedruu the Greathearted, where you can grab your Mountain and pin the Guides negative effect on another player