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Abrade is the poster child for red removal, with both artifact destruction and damage on the one card

Shadowspear Theros Beyond Death s Shadowspear is one of the only ways to remove the indestructible and hexproof abilities from your targets

Raise Dead

Rather than being a 1/1 Squirrel or a 2/2 Zombie, they are just Soldiers, Goblins, Squirrels, and Zombies, which means the Unhinged tokens will get the job done no matter what kind of token of these creature types you want to represent

Blocking opponents is one method, but it might not necessarily result in a dead Vampire

While creature removal in Commander is still important, this amount of damage is small-ball in a multiplayer environment