EGFR-IN-1 14 mesylate At the transfected human α4β2

At the transfected human α4β2 neuronal nAChR in K177 cells

THS-044 binding stabilizes the HIF2α PAS-B folded state

The Pyrido[b]indole MDM2 Inhibitor SP-141 Exerts Potent Therapeutic Effects in Breast Cancer Models

InChiKey: CKTWQGHVNRYNCM-UHFFFAOYSA-N

their biological effects and potential molecular targets

EGFR-IN-1 14 mesylate At the transfected human α4β2EGFR IN 1 (compound 24) is an orally active and irreversible L858R T790M mutant selective EGFR inhibitor. EGFR IN 1 potently inhibits Gefitinib resistant EGFR L858R, T790M with 100 fold selectivity over wild type EGFR. EGFR IN 1 displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity. Product information CAS Number: 1625677 63 5 Molecular Weight: 514. 58 Formula: C28H30N6O4 Chemical