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Now, she emerges from the benthic depths engraved with the maddening spirals and nigh-impenetrable coral armor of the home she once feasted upon

Mizzix gains an experience counter every time you cast an instant or sorcery with mana value greater than the number of experience counters, and it gives you a discount on your instants and sorceries per experience counter it has

The place this shows up most is on effects that change power and toughness both temporarily and permanently

So you blow up the planet using Exterminatus

What did not qualify are creatures with conditional unblockable