One really has to work against the tide, because although we now have a plethora of new problems we dont necessarily have a new range of medicine
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Urza's Command can drop the power of other player's dorks out of nowhere, make a Powerstone, make a tapped Construct token to win the game, and then scry and draw, so I think that the Construct and scry and card draw are the default here, and that's pretty good for four mana instant speed
And they now sell for over $1 million
As usual, achieving these conditions is often counterproductive to winning the game sooner
A friend who has played far too much mono-red