One is focused on humans and +1/+1 counters
Unless youre building a deck specifically to counter poison, youre never going to include that card
Many players prefer a larger cube because it allows them to play two eight-player drafts without having to reshuffle, and they'll never see the same card twice
Unless you have some big-brain plan going on, though, it would be a waste since the targeted permanent wont actually be destroyed
Having the choice of a +1/+1 counter, vigilance, first strike, or menace provides a lot of flexibility, especially with cards that could add additional ability counters
Below are some of the best options available to you on a budget, along with some of the best targets they can grab for you