There are several factors that impact whether a card is among the rarest MTG cards of all time, from the size of the print run to the grading of the card, autographs to misprints, but the biggest one is the Reserved List
This can be seen by looking at the decks commander, Ixhel, Scion of Atraxa
As speculated by TCGplayer, there could be several factors contributing to the card's massive price point, most obviously the fact that's from the recent Twilight Masquerade set which is still relatively new
Mega Scizor EX inflicts 100 DMG for 3x Metal Energy, but if it has moved to the Active Spot from the Bench, it dishes out a mighty impressive 150 DMG
D/D/D Divine Zero King Rage 3 Dark Contract with the Gate 1 Dark Contract with the Swamp King 1 Dark Contract with the Entities 3 Duelist Alliance 2 Jack-In-The-Hand 1 Dark World Reinforcements 1 Fusion Substitute 1 Dark Contract with the Witch 1 Dark Contract with the Eternal Darkness 1 Pendulum Dimension 1 Pendulum Switch 1 Pendulum Reborn 2 D/D/D Abyss King Gilgamesh 2 D/D/D Flame King Genghis 1 D/D/D Oracle King DArc 1 D/D/D Flame High King Genghis 1 D/D/D Dragonbane King Beowulf 1 D/D/D Super Doom King Purple Armageddon 1 D/D/D Wave King Caesar 1 D/D/D Marksman King Tell 1 D/D/D Wave High King Caesar 1 D/D/D Duo-Dawn King Kali Yuga 1 D/D/D Super Doom King Dark Armageddon 1 D/D/D Cursed King Siegfried 1 D/D/D Gust High King Alexander Deck 3: Akaba Reiji Style D/D Deck 3 Go
Yes, this Ishizu support is super flexible, and yes, I can probably guarantee that they will show up again in the future