You also need to make sure you hit your land drops, either with draw effects (Qiqirn Merchant and Adventurers Airship provide usable bodies as well as draw smoothing) or cards that directly give you lands or mana (World Map, landcyclers, Blitzball)
Players must follow all applicable timing rules for casting spells with the permission granted by Ian Malcolm, Chaotician's last ability
The layout updates in real time
If an ability triggers "whenever you tap" something for mana and produces mana, that triggered mana ability won't be affected by Nyxbloom Ancient
If you have an Asceticism in play, or a Heroic Intervention in hand, you can play without fear
That said, it has synergies here and there with loot effects or effects that require you to discard a card to play, so its a nice role-player in a discard-heavy strategy