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I think I'm gonna go pharmaceutical

If were talking about cards that are annoying to play against I dont think many cards can top Coalition Honor Guard, but even so Jetting Glasskite comes close

Cabal Coffers Flipped Itlimoc, Cradle of the Sun Nykthos, Shrine to Nyx Aside from accelerating you significantly, it can also untap lands that enter tapped, and provide you a second go on Maze of Ith and Spires of Orazca, among other effects

Thriving Rats: [Category 2] ETB yield is 2 Energy for 2 mana, then you can spend 2 Energy on a counter

The inclusion of Magic: The Gathering Special Guests cards continues through Modern Horizons 3 , featuring popular reprints like Grief, Dismember, and Thought-Knot Seer

Norin's trigger can let you retrigger ETBs, but having to recast the things that get blocked is a pretty big problem