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The best payoffs here in Commander are for artifact-heavy decks of different kinds

More recent cards like Lolth, Iymrith, Lier, Avabruck Caretaker, Toxrill and even Hullbreaker Horror all allow opponents clear windows for interaction

Yes, Channel is a key card in 2 combo(s) in our combo database, linked from the Combos section of this page.

Then, finish up your turn with its Ninja Spinner attack which has the potential to do 200 damage

Archangel Avacyn's delayed triggered ability won't cause it to transform back into Archangel Avacyn if it has already transformed into Avacyn, the Purifier, perhaps because several creatures died in one turn

Murders at Karlov Manor