The Wandering Emperor Rounding out our top 10 as the most impactful card in Alchemy is The Wandering Emperor
The artwork still puts a focus on Mother Gothel, showing her wrapped in strands of golden magic
Princess Power, the Amber/Sapphire combo, is very accommodating for more cautious play as you feel out the game
Winter Moon is a lot fairer than Winter Orb, and though I think its pretty reasonable for mono-color decks to drop, the social contract is likely to keep it away from most tables
Chapter II protects you from early aggression, and Chapter III should draw you at least two cards and potentially more (say, an opponent is playing mana creatures)
Blood Rite The Vampire deck stands out to me as the most relevant to supporting its corresponding type in a Cube, with meaningful support up and down the mana curve and notably offering some cheap white Vampires, which we really only see on Ixalan