Aggressive Limited decks often use this cards to great effect, but they don't typically see much play in Constructed
You can also probably get away with just running one copy in the deck if you have a card you use to add a little utility or support to your strategy, or one that you use as your silver bullet against certain strategies that are more common in the metagame
Since that time of New Phyrexia , there is much more poison available outside of green and black that one of the best proliferating commanders in Kilo, Apogee Mind is a possibility
or, at least, the opponent has had a chance to catch up
You get to this point by drawing cards and basically preventing your opponent from killing you
So you can either gain more control by drawing cards from your deck, or you can deal a free two damage on any other character in play