You can start ramping as early as turn two with this guy, and the First Strike means youre less likely to have to trade him off to do so
The life payment is much more manageable in EDH, but in certain grindy Standard matches, youll praise Ketramose, no doubt
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Making 2/2 tokens with vigilance at a rate of one token for three mana, two tokens for four mana, three tokens for five mana, etc is honestly quite good, allowing you play both offense and defense as well as put a bunch of material in play as the game goes on
Anax and Cymede & Kynaios and Tiro's last ability won't trigger when a copy of a spell is created on the stack targeting Anax and Cymede & Kynaios and Tiro or when a spell's targets are changed to include Anax and Cymede & Kynaios and Tiro
"Change of Heart" glitch: If you use "Change of Heart" more than once in the same turn (for example, by using it once, flipping "Magician of Faith" and returning it to your hand, and then using it again), only the last card you use "Change of Heart" on will return to your opponent's field at the end of your turn