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Smiles: CC1CCN(CC1)C1=CC=C(C=C1C(F)(F)F)NC(=O)C1C=CC(CN2CCOCC2)=CC=1
Pilaralisib (XL147) displays potent inhibitory activity against Class I PI3K isoforms p110α
and 8 hours
PubMed PMID: 12469943
RKI-1447 suppressed phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells
SKI-II - CAS# 312636-16-1 size:10mg solid Smiles: CC1CCN(CC1)C1=CC=C(C=C1C(F)(F)F)NC(=O)C1C=CC(CN2CCOCC2)=CC=1SKI II, CAS No. 312636 16 1, is a selective non lipid inhibitor of sphingosine kinase (IC50 = 0. 5 M). nhibits acute myelogenous leukemia cell growth in vitro and in vivo. SKI II was more efficient than two known SphK1 inhibitors SK1 I and FTY720 in inhibiting AML cells. Meanwhile, it induced dramatic apoptosis in above AML cells, and the cytotoxicity by SKI II was almost reversed by the general caspase inhibitor z VAD fmk. SKI II treatment inhibited
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