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A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase
Indigo red
NMR and surface plasmon resonance biosensor studies confirm COH29 binding to the proposed ligand-binding pocket and offer evidence for assembly blockade of the RRM1-RRM2 quaternary structure
211(1):39-51
U0126 hostatin A (TSA) A noncovalent class of papain-likeU0126 is a potent and selective non competitive inhibitor of MAP kinase. Inhibits MEK 1 and MEK 2 (IC50 values of 0. 07 and 0. 06 M respectively). Product information CAS Number: 109511 58 2 Molecular Weight: 380. 49 Formula: C18H16N6S2 Synonym: U 0126 Related CAS Number: 1173097 76 1 (U0126 EtOH) Chemical Name: bis({amino[(2 aminophenyl)sulfanyl]methylidene})butanedinitrile Smiles: NC1=CC=CC=C1SC(N)=C(C#N)C(C#N)=C(N)SC1=CC=CC=C1N InChiKey: