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and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3
ClH/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18
CAS Number: 1233855-46-3
US20140011855A1
Smiles: CC1=NC2=CC=C(C=C2N1CC1=CC=C(Cl)C=C1Cl)C(=O)NS(=O)(=O)CCCCC
Tankyrase Inhibitors (TNKS) 49 Size:Contact [email protected] for quotation and competitively inhibits dihydrofolate reductaseTankyrase Inhibitors (TNKS) 49 is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0. 1nM . Tankyrase 1 and tankyrase 2 are members of PARP family. They can use NAD+ as substrates to transfer ADP ribose polymers onto tagert proteins. The tankyrase are found to bind to PARSylate axin proteins which are the negative regulator of Wnt pathway. It makes tankyrase to be targets in treatment for adenomatous polyposis
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