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LXH254 is a potent B/C RAF inhibitor extracted from patent WO2018051306A1
30(36)-octaene-2
An ascending dose PK study in female athymic nude mice shows that the rate of compound release is maximal at 120 mg/kg and all clearance mechanisms can be saturated at 240 mg/kg
Solubility: DMSO : ≥ 32 mg/mL (102
Thalidomide-NH-C8-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology
4-Octyl Itaconate 18014 LXH254 is a potent B/C4 Octyl Itaconate is a cell permeable Itaconate derivative. Itaconate is an anti inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Product information CAS Number: 3133 16 2 Molecular Weight: 242. 31 Formula: C13H22O4 Chemical Name: 2 methylidene 4 (octyloxy) 4 oxobutanoic acid Smiles: CCCCCCCCOC(=O)CC(=C)C(O)=O InChiKey: KBASUIDPDITQHT UHFFFAOYSA N InChi: InChI=1S C13H22O4 c1 3 4 5 6 7 8 9 17 12(14)10 11(2)13(15)16 h2
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