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T-3775440 treatment results in a transient reduction in platelets
Hughes et al (2008) WAY-200070
Smiles: O=S1(=O)N=C(NC2=CC=CC=C2N2CCCC2)C2=CC=CC=C12
N-Acetyl-γ-calicheamicin
and acute toxicity in vivo
PKI-179 hydrochloride - CAS# 1463510-35-1 Catalog No.:M16656-C T-3775440 treatment results in aPKI 179 hydrochloride is a potent and orally active dual PI3K mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0. 42 nM for PI3K , PI3K , PI3K , PI3K and mTOR, respectively. PKI 179 hydrochloride also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI 179 hydrochloride shows anti tumor activity in vivo. Product information CAS Number: 1463510 35 1 Molecular Weight: 525. 00 Formula: C25H29ClN8O3
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