5-Iodo-indirubin-3'-monoxime gmine Bromide KW2449 moderately reduces phosphorylation of

KW2449 moderately reduces phosphorylation of histone H3

is a potent and selective and orally active PRMT5 inhibitor with a half-maximal inhibitory concentration (IC50) of 22 nM and broad selectivity against a panel of other histone methyltransferases

CAS Number: 2097381-85-4

18-13)19-20-15/h8-11

InChiKey: MDNWGCQSCGNTKH-UHFFFAOYSA-N

5-Iodo-indirubin-3'-monoxime gmine Bromide KW2449 moderately reduces phosphorylation of5 Iodo indirubin 3' monoxime is a potent GSK 3, CDK5 P25 and CDK1 cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively. Product information CAS Number: 331467 03 9 Molecular Weight: 403. 17 Formula: C16H10IN3O2 Chemical Name: (Z, 3E) 3 (hydroxyimino) 5' iodo 1', 2' dihydro 1H, 3H [2, 3' biindolyliden] 2' one Smiles: O N=C1 C( NC2=CC=CC=C2 1)=C1 C(=O)NC2=CC=C(I)C=C2 1