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The drug is metabolized and activated in the liver
is an anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers (canker sores)
and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts
and has moderate inhibitory activity against monoamine oxidases MAO-A and MAO-B with IC50 ~1
InChi: InChI=1S/C58H66N10O9/c59-27-13-12-22-46-52(69)64-47(30-38-23-25-42(26-24-38)76-36-39-16-6-2-7-17-39)53(70)66-49(31-37-14-4-1-5-15-37)57(74)68-35-43(77-58(75)61-29-28-60)33-50(68)55(72)67-51(40-18-8-3-9-19-40)56(73)65-48(54(71)63-46)32-41-34-62-45-21-11-10-20-44(41)45/h1-11
Fangchinoline - CAS# 436-77-1 Catalog No.:M12401-10 The drug is metabolized andFangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti inflammatory sterilization and anti atherosclerosis. Fangchinoline, a novel HIV 1 inhibitor, inhibits HIV 1 replication by impairing gp160 proteolytic processing. Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK mediated signaling pathway in tumor cells which highly expressed FAK. Fangchinoline induces apoptosis
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