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PF 1022A (1-100 μg/mL) completely inhibits larval movement at most examination points
It is an analog of clinical IDH2 inhibitor AG-221 by Thomson Reuters Integrity analysis
AMD 3465 treatment stimulates the phosphorylation of Erk1/2 in U87 and Daoy cells
Karlsson JJ
and was discovered by an imaging-based screen
ISX9 - Neurogenic Modulator. CAS# 832115-62-5 0249 PF 1022A (1-100 μg/mL) completelyISX9, CAS No. 832115 62 5, is a neurogenic modulator. It mediates neuroD reporter gene induction via activation of Ca2+ influx, and increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. It induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. ISX9 is also shown to induce cardiomyogenic differentiation of Notch activated epicardium
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