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RO5256390 can be used to reduce multiple behavioral effects of drugs of abuse through their actions on the mesocorticolimbic system
InChi: InChI=1S/C35H51N7O8/c1-40-24-30(48-20-19-47-18-17-46-16-15-45-14-13-43)21-29(40)26-49-34-38-32-22-37-10-8-31(32)33(39-34)41-11-12-42(28(23-41)7-9-36)35(44)50-25-27-5-3-2-4-6-27/h2-6
InChiKey: ODLGMSQBFONGNG-JVZYCSMKSA-N
Cancer Ther
Archives of Biochemistry and Biophysics Volume 385
MS31 Size:Contact [email protected] for quotation RO5256390 can be used toMS31 is a potent, highly affinity and selective fragment like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 potently inhibits binding of trimethyllysine containing peptides to SPIN1. MS31 is not toxic to nontumorigenic cells. Product information CAS Number: 2366264 12 0