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22)11-7-5-10(6-8-11)18-14-9-15(19)12-3-1-2-4-13(12)16(14)20/h1-9
CPI203 could be dosed to the mice by oral administration at 5 mg/kg twice per day for 7 days
GSK-2981278 markedly and potently inhibits IL-17A and IL-22 protein secretion in a concentration dependent manner (IC50 = 3
LY 2109761
2013 Oct 8
CK-1827452 - CAS# 873697-71-3 228 22)11-7-5-10(6-8-11)18-14-9-15(19)12-3-1-2-4-13(12)16(14)20/h1-9CK 1827452, CAS No. 873697 71 3, is a cardiac specific myosin activator. It is clinically tested for its role in the treatment of left ventricular systolic heart failure. CK 1827452 specifically targets and activates myocardial ATPase and improves energy utilization. CK 1827452 improves systolic function by increasing the systolic ejection duration stroke volume, without consuming more ATP energy, oxygen or altering intracellular calcium levels