Pimelic Diphenylamide 106 nogin 3)12(18)14(23)20(24)19(10

3)12(18)14(23)20(24)19(10

has IC50s of 7

This conversion is practically complete

triggering rapid accumulation of polyubiquitinated proteins

8-dihydroquinoline-5-sulfonic acid

Pimelic Diphenylamide 106 nogin 3)12(18)14(23)20(24)19(10Pimelic Diphenylamide 106 is a slow, tight binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs. IC50 value: 150 nM (HDAC1), 370 nM (HDAC3), 760nM(HDAC2)Target: HDAC in vitro: Pimelic Diphenylamide 106 has preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1. Pimelic Diphenylamide 106 exhibits weaker inhibitory