the activity of CZ415 against the human cardiac ion channel hERG is assessed in a whole-cell patch-clamp assay in HEK293 cells resulting in an IC50 of 48 μM
VAL-083 crosses the blood brain barrier (BBB) and appears to be selective for tumor cells
which contributes to the current understanding of the functional association between PPZ and PKM2(The human M2 isoform of pyruvate kinase)[2]
12)78)59(77)79-49(39(10)18-2)58(76)66(15)48(37(7)8)53(71)62-43(33-40-26-21-19-22-27-40)54(72)64(13)45(34-41-28-23-20-24-29-41)56(74)68-31-25-30-44(68)51(69)63-46/h19-24
8 nmol/rat) had no effect
TC OT 39 Catalog No.:M23225-C the activity of CZ415 againstProduct information CAS Number: 479232 57 0 Molecular Weight: 600. 78 Formula: C32H40N8O2S Chemical Name: (Z,2S) 2 (4 methyl 1,4 diazepane 1 carbothioyl) N [(2 methyl 4 {4 methyl 2,4,5,9 tetraazatricyclo[8. 4. 0. 0,]tetradeca 1(14),3(7),5,10,12 pentaene 9 carbonyl}phenyl)methyl]pyrrolidine 1 carboximidic acid Smiles: CC1=CC(=CC=C1C N=C(\O) N1CCC[C@H]1C(=S)N1CCCN(C)CC1)C(=O)N1CC2C=NN(C)C=2NC2=CC=CC=C12 InChiKey: KSNHHKZYKYNBEI NDEPHWFRSA N InChi: