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Epub 2012 Aug 3
Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834
Chemical Name: 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3
Formula: C6H13NO2
which are inhibited with IC50s in the range of 2 to 3 μM
Resminostat - CAS# 864814-88-0 O-206 Epub 2012 Aug 3Resminostat, also known as 4S 201 and RAS2410, is an orally bioavailable inhibitor of histone deacetylases (HDACs) with potential antineoplastic activity. Resminostat binds to and inhibits HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, inhibition of the transcription of tumor suppressor genes, inhibition of tumor cell division and the induction of tumor cell apoptosis. Product
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