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Suppression of Plk1 in vivo by using GSK461364 results in mitotic arrest with aberrant mitotic figures consisting of monopolar or collapsed mitotic spindles
without cardiotoxicity or genotoxicity
1997 Apr 25
U0126-EtOH inhibits T cell proliferation in response to antigenic stimulation or cross-linked anti-CD3 plus anti-CD28 Abs without effect on IL-2-induced proliferation by down-regulating IL-2 mRNA levels
The effect is more apparent in the 0
(3R,4S)-Tofacitinib - CAS# 1092578-46-5 lexin Hydrochloride Suppression of Plk1 in vivoTofacitinib, also known as tasocitinib, CP 690550, is a Janus kinase (JAK) inhibitor. Product information CAS Number: 1092578 46 5 Molecular Weight: 312. 37 Formula: C16H20N6O Chemical Name: 3 [(3R,4S) 4 methyl 3 [methyl({7H pyrrolo[2,3 d]pyrimidin 4 yl})amino]piperidin 1 yl] 3 oxopropanenitrile Smiles: CN([C@H]1CN(CC[C@@H]1C)C(=O)CC#N)C1N=CN=C2NC=CC2=1 InChiKey: UJLAWZDWDVHWOW AAEUAGOBSA N InChi: InChI=1S C16H20N6O c1 11 5 8 22(14(23)3 6 17)9
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