OF-1 - BRPF Bromodomain Inhibitor. CAS# 919973-83-4 Catalog No.:M60222-10S It can suppress proliferation

It can suppress proliferation

and induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines

The selectivity of protein kinase inhibitors: a further update

is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor with IC50 ~424 nM

Oral administration of GW0742 causes an increase in expression of Angptl4 and Adrp mRNA (known PPARβ/δ target genes) in wild-type mouse colon epithelium

OF-1 - BRPF Bromodomain Inhibitor. CAS# 919973-83-4 Catalog No.:M60222-10S It can suppress proliferationOF 1, CAS No. 919973 83 4, is the potent and selective BRPF (BRomodomain and PHD Finger containing) inhibitor. It binds to BRPF1B with a KD of 100 nM (ITC), to BRPF2 with a KD of 500 nM (ITC) and to BRPF3 with a KD of 2. 4 mM (ITC). It has general >100 fold selectivity against other bromodomains (39 fold selectivity over BRD4). OF 1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 M and also