APS-2-79 - CAS# 2002381-25-9 size:2mg solid UNC2170 was used at 10-30

UNC2170 was used at 10-30 µM final concentration in various in vitro assays

PubMed PMID:23794264

Epub 2016 Oct 25

2014 Dec 12

is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM

APS-2-79 - CAS# 2002381-25-9 size:2mg solid UNC2170 was used at 10-30APS 2 79, CAS No. 2002381 25 9, is a KSR dependent MAPK modulator. APS 2 79 modulates KSR dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR bound MEK (mitogen activated protein kinase kinase). APS 2 79 increased the potency of several MEK inhibitors specifically within Ras mutant cell lines by antagonizing release of negative feedback signalling,