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Pemafibrate 18971 7) and efficacious (90-98% ofPemafibrate is a potent PPAR agonist, with EC50s of 1 nM, 1. 10 uM and 1. 58 uM for h PPAR, h PPAR and h PPAR, respectively, and possesses lipid lowering effect. Pemafibrate is a potent PPAR agonist, with EC50s of 1 nM, 1. 10 uM and 1. 58 uM for h PPAR, h PPAR and h PPAR, respectively. Pemafibrate is more than 1000 fold selective towards PPAR than PPAR and PPAR. Pemafibrate (3 mg kg, p. o.) increases plasma h apoA I in human apoA I (h apoA I)