GGTI-298 TFA - CAS# 1217457-86-7 60002 Smiles: O=C1C2=NC3=NON=C3N=C2C2=CC=CC=C21

Smiles: O=C1C2=NC3=NON=C3N=C2C2=CC=CC=C21

of apparent translational significance

Harmine was dosed orally to obese db/db mice at 30 mg/kg

3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid

5-dihydro-1H-imidazol-2-yl)phenyl)urea)

GGTI-298 TFA - CAS# 1217457-86-7 60002 Smiles: O=C1C2=NC3=NON=C3N=C2C2=CC=CC=C21GGTI 298 TFA, CAS No. 1217457 86 7, is a potent geranylgeranyltransferase I (GGTase I) inhibitor with potential antitumor actrivity. GGTI 298 disrupts MAP kinase activation and G(1) S transition in Ki Ras overexpressing transformed adrenocortical cells. GGTI 298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin dependent kinase inhibitors. A potential mechanism for GGTI 298 antitumor activity. GGTI 298 arrests human tumor