Tyk2-IN-5 ino pyrazole Smiles: CC(C)(C)C1C=CC(=CC=1)C(=O)NC1C=CC(=CC=1)NC1C=CC=CC=1

Smiles: CC(C)(C)C1C=CC(=CC=1)C(=O)NC1C=CC(=CC=1)NC1C=CC=CC=1

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

Smiles: CC(C)(C)[Si](C)(C)OC[C@H]1O[C@H](C[C@@H]1O)N1C=NC2C1=NC=NC=2NC(=O)C1C=CC=CC=1

10(4):298-304

without affecting the differentiation of Th1 and Th17 cells

Tyk2-IN-5 ino pyrazole Smiles: CC(C)(C)C1C=CC(=CC=1)C(=O)NC1C=CC(=CC=1)NC1C=CC=CC=1Tyk2 IN 5 (compound 6) is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0. 086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFN. Highly effective in inhibiting IFN production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model. Product information CAS Number: 1797432 62 2 Molecular Weight: 434. 43 Formula: C21H19FN8O2 Chemical Name: N [(1R,2S) 2 fluorocyclopropyl] 8