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AZD-2461 (500 nM) shows inhibitory activity against DNA single-strand break repair in human A459 cells
InChiKey: SGRYPYWGNKJSDL-UHFFFAOYSA-N
3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17
InChiKey: HRGZELWFPQCNNG-NQVPMCNCSA-N
Fuentes-Pesquera A
CHK1-IN-2 inone D AZD-2461 (500 nM) shows inhibitoryCHK1 IN 2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM. Product information CAS Number: 912367 45 4 Molecular Weight: 366. 48 Formula: C20H22N4OS Chemical Name: 4 {[(2R,3S) 2 methylpiperidin 3 yl]amino} 2 phenylthieno[3,2 c]pyridine 7 carboxamide Smiles: C[C@H]1NCCC[C@@H]1NC1N=CC(C(N)=O)=C2SC(=CC2=1)C1C=CC=CC=1 InChiKey: LMQOZGSVTQQPFU WBMJQRKESA N InChi: InChI=1S C20H22N4OS c1 12 16(8 5 9 22 12)24 20 14 10 17(13 6 3 2 4 7 13)26