γ-Linolenic Acid methyl ester esinol dimethyl ether 30-60 mins) inhibits IL-1β-induced NF-κB

30-60 mins) inhibits IL-1β-induced NF-κB activation and decreases the phosphorylation of IKKα/β

⁸]hexadeca-3

KU-0063794

Smiles: CN1[C@@H]2CCC3=CC(Cl)=CC=C3[C@H]2CCC1=O

25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10

γ-Linolenic Acid methyl ester esinol dimethyl ether 30-60 mins) inhibits IL-1β-induced NF-κBLinolenic Acid methyl ester is a weak leukotriene B4 (LTB4) receptor antagonist. LTB 4, a potent neutrophil chemoattractant, is present at high concentrations in psoriatic lesions, bronchoalveolar lavage in asthmatics and rectal dialysates in patients with inflammatory bowel disease. In vitro: Linolenic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA containing diets